Effects of Enalapril on Blood Glucose Level and Interaction with the Oral Anti-diabetic Drugs in Alloxan-induced Diabetic Rats

نویسنده

  • NEERAJ K. AGRAWAL
چکیده

Aim: To evaluate the effect of Enalapril on blood glucose level in normal rats and interaction with the oral anti-diabetic drugs in Alloxan-induced diabetic rats. Method: The rats were classified into nine groups (n = 6).The Group I –II were normal and Group III –IX were diabetic. The experimental diabetes in rats was induced by intra-peritoneal injection of Alloxan monohydrate (135 mg/kg body weight). The Enalapril at the dose of 3.2 mg/kg body weight was administered to the normal rats to find-out the effect on blood glucose level. In diabetic groups, the Enalapril was given along with three Oral anti-diabetic drugs to know the any alteration on blood glucose level .All drugs administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) and blood glucose estimation was done. Results: It was observed that in normal rats the Enalapril slightly reduced the blood glucose level at all time points which was not significant (P>0.05) but in Alloxan-induced diabetic rats Enalapril exhibited the anti-hyperglycemic activity at all time points in highly significant manner (P≤0.001). Conclusion: The present study has showed that The Enalapril has significant anti-hyperglycemic activities which enhance the effect of oral antidiabetic drugs in diabetic animal. It is therefore advisable to prescribe and use of ACE inhibitors with anti-diabetic drugs carefully with necessary dose adjustment to avoid adverse hypoglycemic episodes in diabetic individuals.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Anti-hyperglycemic Effects of Saffron and its Active Constituents, Crocin and Safranal, in Alloxan-Induced Diabetic Rats

Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. Oral crocin is not absorbed and is h...

متن کامل

Effects of Turnera ulmifolia (Linn.) Leaves on Blood Glucose Level in Normal and Alloxan-Induced Diabetic Rats

The methanolic extract of leaves of Turnera ulmifolia L was evaluated for its effect on blood glucose in alloxan-induced diabetic and euglycemic rats. The extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. Glibenclamide (10 mg/kg, p.o.) was used as standard for control group. In euglycemic rat, extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. Extr...

متن کامل

Anti-hyperglycemic Effects of Vaccinium arctostaphylos L. Fruit and Leaf Extracts in Alloxan-Induced Diabetic Rats

Background: Vaccinium arctostaphylos L. (Caucasian whortleberry) fruit is used as an anti-hyperglycemic agent for treatment of diabetes mellitus. Objective: The effects of whortleberry fruit and leaf extracts on the blood levels of fasting glucose, HbA1c (glycosylated hemoglobin), insulin, creatinine and liver enzymes SGOT and SGPT in alloxan-diabetic rats as well as LD50s of the extracts in ...

متن کامل

Evaluation of the Effect of Perindopril and its Combination with Oral Anti-Diabetic Drugs on Blood Sugar Levels in Diabetic Wistar Rats

It is well known scientifically that ACE (Angiotensin converting enzyme) inhibitors prevent the development and progression of incipient or established nephropathy and delay the progression of diabetic retinopathy hence these drugs are routinely prescribed with the oral anti-diabetic drugs in these conditions. The actual scenario of impact of ACE inhibitors on blood glucose is still controversi...

متن کامل

Effects of safflower oil on FBS and lipid profile in alloxan induced diabetic rats and its mechanism

Background & Aim: Diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). Nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. Experimental: This study aimed at assessing the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013